Edwardsiella tarda MliC : a lysozyme inhibitor that participates in 1 pathogenesis in a manner that parallels Ivy
نویسندگان
چکیده
4 Mo-fei Li 1,2 , Chong Wang 1,2 , and Li Sun 1,3 * 5 6 7 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of 8 Sciences, 7 Nanhai Road, Qingdao 266071, China 1 ; University of Chinese Academy of Sciences, 9 Beijing 100049, China 2 ; Collaborative Innovation Center of Deep Sea Biology, Zhejiang University, 10 Hangzhou 310058, China 3 11 12 13 14 15 *To whom correspondence should be addressed 16 17 Mailing address: 18 Institute of Oceanology 19 Chinese Academy of Sciences 20 7 Nanhai Road 21 Qingdao 266071, China 22 Phone: 86-532-82898829 23 Fax: 86-532-82898829 24 Email: [email protected] 25 26
منابع مشابه
Edwardsiella tarda MliC, a lysozyme inhibitor that participates in pathogenesis in a manner that parallels Ivy.
Edwardsiella tarda, a bacterial pathogen to farmed fish as well as humans, possesses the genes of two lysozyme inhibitors, ivy and mliC (ivy(Et) and mliC(Et)). We recently studied IvyEt and found it to be implicated in E. tarda virulence. In the present study, we characterized MliC(Et) in comparison with Ivy(Et) in a turbot model. MliC(Et) contains the FWSKG motif and two cysteines (C33 and C98...
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Lysozymes are ancient and important components of the innate immune system of animals that hydrolyze peptidoglycan, the major bacterial cell wall polymer. Bacteria engaging in commensal or pathogenic interactions with an animal host have evolved various strategies to evade this bactericidal enzyme, one recently proposed strategy being the production of lysozyme inhibitors. We here report the di...
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